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ТЕРАПЕВТИЧЕСКИЕ И/ИЛИ ДИАГНОСТИЧЕСКИЕ НАНОНОСИТЕЛИ, НАЦЕЛЕННЫЕ НА МАТРИКСНЫЕ МЕТАЛЛОПРОТЕАЗЫ (ММП)
专利权人:
МАЛЛИНКРОДТ Эл-Эл-Си (US)
发明人:
РОДЖЕРС Томас Е. (US),ФРЕСКОС Джон Н. (US)
申请号:
RU2014123622
公开号:
RU2014123622A
申请日:
2012.11.30
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A composition for targeted delivery, comprising: (a) nanocarriers comprising a therapeutic or diagnostic agent, or a combination thereof and (b) a conjugate having the formula: A- (LPEG) -MMP gdeA a connecting component for attaching said conjugate to said nanocarriers (LPEG) is selected from: (i) a linking group having 1-3 linear unit of polyethylene glycol components, (ii) a linking group having the formula [(EG) (P)] wherein each EG is ethylene glycol group independently selected from the group consisting of triethylene glycol, tetraethylene glycol, pentaetilenglikolya, hexaethylene glycol, and octaethylene glycol geptaetilenglikolya Ρ is phosphoryl or thiophosphoryl group, am is an integer from 1 to 20 or (iii) a linking group having the formula -Ζ-Ζ-Ζ-, in kotoroyZi Znezavisimo selected from the group consisting of a PEG component having a certain length and W, wherein W is an amino acid and the subscript n is an integer from 0 until 3 iΖvybran from the group consisting of a PEG component having a predetermined length, and a connecting group selected from an amide, thioamide, ester, carbamate or urea compounds for Ζi Ζ MMPyavlyaetsya MMP.2 enzyme inhibitor. A composition for targeted delivery of Claim. 1, wherein (LPEG) is -Ζ-Ζ-Ζ-.3. . The composition for targeted delivery of claim 2, wherein Ζyavlyaetsya W Ζvybran of amide, thioamide, ester, carbamate or urea Ζyavlyaetsya a PEG component having a certain dlinu.4. A composition for targeted delivery of claim. 3, in which the subscript n is 3.5. A composition for targeted delivery of claim. 3, in which the subscript n is 2.6. composite
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