AHMED, Gulzar,BOHNSTEDT, Adolph,BRESLIN, Henry Joseph,BURKE, Jason,CURRY, Matthew A.,DIEBOLD, James L.,DORSEY, Bruce,DUGAN, Benjamin J.,FENG, Daming,GINGRICH, Diane E.,GUO, Tao,HO, Koc-Kan,LEARN, Keit
申请号：
ES07861484
公开号：
ES2555803T3
申请日:
2007.10.23
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula I or II ** Formula ** or a pharmaceutically acceptable salt form thereof, wherein R 1 is chlorine； R2 is a group selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-15 aryl, C3-10 cycloalkyl, 3-15 membered heterocycloalkyl, and 5-15 membered heteroaryl, in which the group R2 is optionally substituted by one or more members independently selected from halogen, -NO2, -OR20,>； = O, - C (>； = O) R20, -C (>； = O) OR20, -C (>； = O) NR22R23, -NR20R21, C1-6- (R25) x alkyl, C6-15- (R25) x aryl, 5-15 membered heteroaryl- (R25) x, C3-10- (R25) x cycloalkyl, 3-heterocycloalkyl -15 members- (R25) x, pseudohalogen, - S (>； = O) nR20, -S (>； = O) 2NR22R23, -OCH2F, -OCHF2, -OCF3, NHOH, -OC (>； = O) R20, OC (>； = O) NR22R23, - NR20C (>； = O) R21, -NR20C (>； = O) OR21, -NR20S (>； = O) 2R21, NR20C (>； = O) NR22R23, -NR20S (>； = O) 2NR22R23 , and -SCF3； R3, R4, and R5 are independently selected from H, halogen, -NO2, -OR30, -C (>； = O) R30, -C (>； = O) OR30, - C (>； = O) NR32R33, -NR30R31, C 1-6 alkyl- (R35) x, C6-15 aryl- (R35) x, 5-15 membered heteroaryl- (R35) x, C3-10 cycloalkyl- (R35) x, 3-15 membered heterocycloalkyl- ( R35) x, pseudohalogen, -S (>； = O) nR30, - S (>； = O) 2NR32R33, -OCH2F, -OCHF2, -OCF3, NHOH, -OC (>； = O) R30, -OC (>； = O ) NR32R33, NR30C (>； = O) R31, - NR30C (>； = O) OR31, -NR30S (>； = O) 2R31, - NR30C (>； = O) NR12R33, -NR30S (>； = O) 2NR32R33, and -SCF3 ； A1, A2, A3, A4, and A5 are each independently -CZ1Z2-, - (CZ1Z2) 2- -C (>； = O) -, - NZ3-, -S-, -S (>； = O) -, -S (>； = O) 2-, or -O-, with the condition at most of A1, A2, A3, A4, and A5 is - (CZ1Z2) 2-, in which: (a) when any of Z1, Z2, and Z3 are found in adjacent atoms, they can form a bond between the atoms, (b) any of Z1, Z2, and Z3 can be independently selected from H, halogen, -NO2, -OR40, - C (>； = O) R40, -C (>； = O) OR40, -C (>； = O) NR42R43, -NR40R41, C1-6 alkyl- (R45) x, C6-15 aryl- (R45) x, 5- heteroaryl
