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ANTI-TUMOR AGENT ACTING COMPOUNDS WITH AN INHIBITING EFFECT TO KINASES IN COMBINATION
专利权人:
ЭЙСАЙ Ар ЭНД Ди МЕНЕДЖМЕНТ КО.; ЛТД. (JP)
发明人:
НАКАГАВА Такаюки (JP),МАЦУСИМА Томохиро (JP),ФУНАХАСИ Ясухиро (JP)
申请号:
RU2012158142/15
公开号:
RU2012158142A
申请日:
2011.06.23
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. An antitumor drug for combined use: a compound or a pharmaceutically acceptable salt thereof represented by formula (I): wherein R 1 is azetidinyl, piperidinyl or -NRR, each of which optionally has a substituent selected from substituent group A, where R and R are the same or different, and each represents a hydrogen atom, C1-6 alkyl or piperidinyl optionally containing C1-6 alkyl, substituent group A consists of hydroxyl, piperazinyl optionally containing meth And azetidinyl optionally having dimethylamino, and R-Ryavlyayutsya same or different and each represents a hydrogen atom or a fluorine atom; and a compound or a pharmaceutically acceptable salt thereof represented by the formula (II): wherein R 1 is C 1-6alkyl or Cycloalkyl, R 1 is a hydrogen atom, C 1-6 alkyl or Calkoxy, and R 1 represents a hydrogen atom or a halogen atom. 2. The antitumor drug of claim 1, wherein the compound represented by formula (I) is one or more compounds selected from the group consisting of: N- (2-fluoro-4 - {[2 - ({[4- ( 4-methylpiperazin-1-yl) piperidin-1-yl] carbonyl} amino) pyridin-4-yl] oxy} phenyl) -N '- (4-fluorophenyl) cyclopropan-1,1-dicarboxamide:, N- [4 - ({2 - [({4- [3- (dimethylamino) azetidin-1-yl] piperidin-1-yl} carbonyl) amino] pyridin-4-yl} oxy) -2-fluorophenyl] -N '- ( 4-fluorophenyl) cyclopropan-1,1-dicarboxamide:, N- {2,5-difluoro-4 - [(2 - {[(3-hydroxyazetidin-1-yl) carbonyl] amino} pyridin-4-yl) hydroxy} phenyl) -N '- (4-fluorophenyl) cyc propan-1,1-dicarboxamide:, N- {2,5-difluoro-4 - [(2 - {[4- (4-methylpiperazin-1-yl) piperidin-1-yl] carbonyl} amino) pyridin-4 -yl] oxy} phenyl) -N '- (4-fluorophenyl) cyclopropane-1,1-dica1. Противоопухолевое лекарственное средство для комбинированного применения:соединения или его фармацевтически приемлемой соли, представленных формулой (I):,где Rпредставляет собой азетидинил, пиперидинил или формулу -NRR, каждый из которых необязательно имеет заместитель, выбранный из группы заместителей А, где Rи Rявляются одинаковыми
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