Thiophene derivatives of formula (I) and a pharmaceutically acceptable salt thereof are provided. These compounds have utility for the treatment or prevention of disorders caused by IgE, such as allergy, type 1 hypersensitivity or familiar sinus inflammation.本發明提供式(I)之噻吩衍生物及其醫藥可接受之鹽類,此等化合物可用於治療或預防由IgE引起的病症,例如過敏、第1型過敏反應或常見的鼻竇炎症。