The new application , Department of this Hair Ming Department Off Yu mono- Seed Swollen handle chrysanthemum Inner esters A and its derivative are extracted from five pawl gold English, and are used with the Should that controls Treatment Dai Xie diseases. The bright middle , The Swollen handle chrysanthemum Inner esters A of this Hair and its derivative can Should with what control Treatment diabetes, hypoglycemic and drop Bile sterol , And can Should Yong Yu System Prepare control Treatment diabetes, hypoglycemic and drop Bile sterol Medical Drug Group close object.本發明係關於一種腫柄菊內酯A及其衍生物之新用途,係萃取自五爪金英,而用於治療代謝疾病之應用。本發明中,該腫柄菊內酯A及其衍生物可應用於治療糖尿病、降血糖以及降膽固醇,並可應用於製備治療糖尿病、降血糖以及降膽固醇之醫藥組合物。