Carotenoid derivative compounds； including pharmaceutical components of these compounds； used in the treatment of high fat, obesity, glucose intolerance, hypertension, insulin resistance, metabolic syndrome, diabetes, glaucoma, Alzheimer's disease, etc.
The object of the present invention is to find a carotenoid compound that is excellent in water solubility. A carotenoid derivative having a formula (I): wherein X represents a carbonyl group or a methylene group, one of R 1 and R 2 represents (a) or (b) and the other represents (a), (b), (c) or a hydrogen atom: (a): -CO-A-B-D wherein A represents an alkylene group an alkenylene group, etc., B represents a formula of -S(O) n - or a formula of -NR 4 CONR 5 - and D represents a hydrogen atom, a carboxy group, etc., (b): -CO-E-F wherein E represents an alkylene group or a formula of -NR 3 - wherein R 3 represents (a1) a hydrogen atom, (b1) an alkyl group etc., and F represents a sulfo group and (c): -CO-G wherein G represents a hydrogen atom, an alkyl group, 1 etc., a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester or amide thereof.COMPUESTOS DERIVADOS DE CAROTENOIDE； COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE； USO EN EL TRATAMIENTO DE HIPERLIPIDEMIA, OBESIDAD, INTOLERANCIA A LA GLUCOSA, HIPERTENSIÓN, RESISTENCIA A LA INSULINA, SÍNDROME METABÓLICO, DIABETES, GLAUCOMA, ENFERMEDAD DE ALZHEIMER, ENTRE OTRAS.
