A method of operation infusion device (100), the following steps are included: actuating fluid conveying device (200), the fluid conveying device is configured to convey predetermined volume according to the delivery profile for including the actuating of multiple fluid conveying devices in each activating, based on the pressure sensed, it determines in the actual volume that fluid conveying device activating conveys whether be predetermined volume, and adjusts the number of the actuating in delivery profile in response to the actual volume of conveying and predetermined volume difference.