Ta-Yuan Chang,Catherine C. Y. Chang,Yohei Shibuya,Zhaoyang Niu
申请号：
US14289996
公开号：
US09388413B2
申请日:
2014.05.29
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
