The present invention relates to a portable medical diagnostic apparatus based on an image sensor capable of managing an individual's disease and health condition, and a medical information management method using the same. The portable medical diagnostic apparatus is configured on the upper surface of the portable medical diagnostic apparatus, A plurality of buttons 130 for inputting commands to start and stop the medical diagnosis of the portable medical diagnostic apparatus, power on / off, and data transmission control commands; And an external strip loader 200 for medical diagnosis according to the opening / closing of the main cover 110, which is formed inside the main body under the main cover 110, A diagnostic sheet 310 for medical diagnosis in the direction of the strip loader mounting area 140 or a diagnostic sheet 310 of various diagnostic kit bodies 301 and 302 for medical diagnosis,An image sensor 160 for acquiring an image of a separator (marker) 320 capable of automatically distinguishing between the sheet strip 300 or various diagnostic kit bodies 301 and 302 for medical diagnosis, An illuminating unit 161 composed of an LED serving as a light irradiating device for clearly photographing the color of the diagnostic sheet strip 300, and an analyzing unit 161 disposed on one side of the main body, for analyzing and storing images sensed by the image sensor 160 A control box 170 for transmitting power to the portable medical diagnostic apparatus and supplying power to the portable medical diagnostic apparatus, and a controller 170 for controlling the power supply and the data to be supplied to the image sensor 160, the illumination unit 161, A portable medical diagnostic apparatus main body 100 configured to supply power and data lines 171; And an upper surface corresponding to the image sensor 160 of the portable medical diagnostic apparatus main body 100 are open and the upper surface of the diagnostic sheet strip 300 or the diagnosis kit body 301 A f