ANTIBODIES THAT BIND TO PSCA PROTEINS, POLYNUCLEOTIDES ENCODING THE SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, METHODS OF PRODUCING THE SAME AND METHODS OF USE THEREOF
Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response； antibodies or T cells reactive with PSCA can be used in active or passive immunization.
