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MAYTANSINOIDS AND THE METHOD OF PREPARATION
专利权人:
发明人:
WIDDISON WAYNE C,CHARI RAVI V J
申请号:
IN1799/DELNP/2011
公开号:
IN2011DN01799A
申请日:
2011.03.10
申请国别(地区):
IN
年份:
2012
代理人:
摘要:
New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the &agr-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new maytansinoids to cell-binding agents. The maytansinoid-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.
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