Joseph A. Tino;Peter T. W. Cheng;Yan Shi;Wei Meng;Denis E. Ryono;Richard B. Sulsky;Scott A. Bolton;Sean Chen
发明人:
Denis E. Ryono,Peter T. W. Cheng,Scott A. Bolton,Sean Chen,Yan Shi,Wei Meng,Joseph A. Tino,Richard B. Sulsky
申请号：
US13012351
公开号：
US08153677B2
申请日:
2011.01.24
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structurewhereinis a heteroaryl ring；R4 is —(CH2)n—Z—(CH2)m—PO(OR7)(OR8),—(CH2)nZ—(CH2)m—OPO(OR7)R9,—(CH2)nZ—(CH2)m—OPO(R9)(R10), or—(CH2)nZ—(CH2)m—PO(R9)(R10)；R5 and R6 are independently selected from hydrogen, alkyl and halogen；Y is R7(CH2)s or is absent； andX, n, Z, m, R4, R5, R6, R7, and s are as defined herein；or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
