The present Invention relates to novel quinoline Derivatives of 2 - amino - 4 - amino - Primary Secondary, their manufacture, Pharmaceutical compositions comprising them and their use as medicines. The active compounds of the present Invention are useful for the Prevention and Treatment of neoplastic and non neoplastic proliferative diseases.El presente invento se relaciona a derivados novedosos de amino-quinoleína 2-primario amino-4-secundario, su manufactura, composiciones farmacéuticas que los comprendan y su uso como medicamentos. Los compuestos activos de la presente invención son útiles para el tratamiento y prevención de enfermedades proliferativas neoplásicas y no neoplásicas.