Provided is a composition that includes oblate spheroidal particles comprising an active agent, such as a therapeutic or imaging agent, and a method for treating or monitoring a physiological condition, such as a disease, by administering the composition to a subject in need thereof. Also provided are methods for making particles that have a volume that can enhance the particles adhesion to a target site in a subjects body for a pre-selected shape of the particles and methods for making particles that have a shape that can enhance particles adhesion to a target site in a subjects body for a pre-selected volume of the particles.
