The present invention provides antibody drug conjugates or antigen binding fragment thereof that bind to 161P2F10B protein, wherein the antibody or antigen binding fragment thereof is conjugated to one or more units of monomethyl auristatin F (MMAF), each unit being conjugated via a linker. Provided are also antibody drug conjugates for use as a medicament, and pharmaceutical compositions that comprise the antibody drug conjugates in a human unit dose form. Further provided are antibody drug conjugates or the pharmaceutical compositions of the invention for use in treating cancer/tumor or inhibiting cancer/tumor growth in a subject.
