Antibodies to human N3pGlu Aβ, compositions comprising such N3pGlu Aβ antibodies, and methods of using such N3pGlu Aβ antibodies for the treatment of a disease characterized by deposition of Aβ including clinical or pre-clinical Alzheimer's disease, Down's syndrome, and clinical or pre-clinical cerebral amyloid angiopathy.本發明係關於人類N3pGlu Aβ之抗體、包含該等N3pGlu Aβ抗體之組合物、及使用該等N3pGlu Aβ抗體治療特徵在於Aβ之沈積的疾病的方法,該疾病包括臨床或臨床前阿茲海默氏症、唐氏症候群及臨床或臨床前大腦類澱粉血管病。