The present invention provides a novel liposome composition containing active compound, wherein the active compound is eribulin or its pharmacologically permissible salt. The present invention also provides a novel method of manufacture of the liposome composition comprising a step in which a liposome dispersion liquid containing liposome is provided, a step in said liposome dispersion liquid is mixed with said active compound, and a step in which said active compound is introduced into the liposome internal phase of said liposome dispersion liquid.
