RESEARCH TRIANGLE INSTITUTE;DIGNITY HEALTH DOING BUSINESS AS ST. JOSEPH'S HOSPITAL MEDICAL CENTER AND BARROW NEUROLOGICAL INSTITUTE;VIRGINIA COMMONWEALTH UNIVERSITY
发明人:
CARROLL, F. IVY,BLOUGH, BRUCE E.,NAVARRO, HERNAN A.,MASCARELLA, S. WAYNE,MURESAN, ANA ZAMFIRA,DAMAJ, M. IMAD,LUKAS, RONALD J.
申请号：
ES11723156
公开号：
ES2546492T3
申请日:
2011.05.20
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound according to the structure: ** Formula ** in which: R1 is optionally substituted C1-10 alkyl； R2 is H10-10 alkyl optionally substituted； R3 and R4 are each independently selected from optionally substituted C1-10 alkyl； X, Y and Z are each independently selected from H； optionally substituted C1-10 alkyl； optionally substituted C1-10 alkoxy； optionally substituted C2-10 alkenyl； optionally substituted C2-10 alkynyl； optionally substituted C6-C12 aryl； alkaryl； arylalkyl； aryloxy； optionally substituted heteroaryl； optionally substituted heterocycle； halo； hydroxyl； halogenated alkyl； an amino group of the formula NH2, NR12H or NR12R13； alkylamino； arylamino； acyl； CN； NO2； N3； CH2OH； CONH2； CONR12R13； CO2R12； CH2OR12； NHCOR12； NHCO2R12； C1-3 alkylthio； sulfate； sulfonic acid； sulfonate ester； phosphonic acid； phosphate； phosphonate； mono-, di- or triphosphate ester； trityl or monomethoxytrityl； R12SO； R12SO2； CF3S； CF3SO2； trialkylsilyl； and diphenylmethylsilyl； or where X and Y, or Y and Z form a condensed aryl ring together with the phenyl ring to which X, Y and Z are attached； and R12 and Ri3 are each independently selected from H or optionally substituted C1-10 alkyl； with the proviso that one or more of X, Y and Z is optionally substituted C6-C12 aryl； or its pharmaceutically acceptable ester, amide, salt, solvate, stereo or geometric isomer.Un compuesto de acuerdo con la estructura:**Fórmula** en la que: R1 es alquilo C1-10 opcionalmente sustituido； R2 es H alquilo C1-10 opcionalmente sustituido； R3 y R4 se seleccionan cada uno independientemente entre alquilo C1-10 opcionalmente sustituido； X, Y y Z se seleccionan cada uno independientemente entre H； alquilo C1-10 opcionalmente sustituido； alcoxi C1-10 opcionalmente sustituido； alquenilo C2-10 opcionalmente sustituido； alquinilo C2-10 opcionalmente sustituido； arilo C6-C12 opcionalmente sustituido； alcarilo； arilalquilo； ariloxi； heteroarilo opcionalmente sustituido； heterociclo opcionalmente susti
