Short-acting Factor VII peptides are disclosed. A shortened half-life is desirable for treatment of acute bleeding and similar disorders. Modification of the sialylation and/or glycosylation of Factor VII and variants thereof produced peptides useful in treating conditions of acute bleeding. Human coagulation Factor VII variants and the polynucleotides encoding such variants, vectors and host cells comprising and expressing such variants, methods of obtaining such variants, methods of using such variants, compositions of the variants, and additional inventive features related thereto are provided herein.Se divulgan péptidos del Factor VII de acción corta. Una vida media acortada es deseable para el tratamiento de hemorragia aguda y trastornos similares. La modificación de la sialización y/o de la glucosilación del Factor VII y de variantes del mismo produjo péptidos útiles en el tratamiento de afecciones de hemorragia aguda.
