Pharmaceutical composition for prevention and treatment of chronic obstructive pulmonary disease comprising extract of Rhus javanica Linne as an active ingredient
PURPOSE: A pharmaceutical composition for preventing and treating chronic obstructive pulmonary disease (COPD) is provided to reduce the number of macrophages, eosinophils, neutrophils, and lymphocytes in bronchoalveloar lavage fluid (BALF) using a Rhus javanica Linne extract, thereby being used as an active ingredient of pharmaceutical products and health foods for preventing and treating COPD. CONSTITUTION: A pharmaceutical composition for preventing and treating COPD contains a Rhus javanica Linne extract as an active ingredient. COPD includes chronic bronchitis or pulmonary emphysema. A composition for health foods for preventing and treating COPD contains the extract as an active ingredient. A pharmaceutical composition for preventing and treating lung diseases contains the extract as an active ingredient. [Reference numerals] (AA) Total inflammatory cell in waste washing solution (×；10^6)； (BB) Gallnut본 발명은 오배자(Rhusjavanica Linne) 추출물을 유효성분으로 함유하는 만성폐쇄성 폐질환(chronic obstructive pulmonary disease； COPD) 예방 및 치료용 약학적 조성물에 관한 것으로, 구체적으로 본 발명의 오배자 추출물은 폐세척액내(bronchoalveloar lavage fluid； BALF) 대식세포, 호산구, 호중구 및 림프구의 수를 감소시키고, 만성폐쇄성 폐질환에 의해 급격히 증가한 IL-6 및 TNF-α 사이토카인, 및 MCP-1 및 MMP-12의 양을 현저하게 낮추는 효과를 가지며, 조직상에서 폐포주위의 염증세포를 유의적으로 감소시키고, 확장된 폐포 크기를 의미있게 감소시키므로 만성폐쇄성 폐질환 예방 및 치료를 위한 의약품 및 건강식품의 유효성분으로 유용하게 사용될 수 있다.
