The present Invention relates to a composition comprising at least one Biological control Agent selected from the group consisting chitinosporus Bacillus (of access aq746 NRRL B - 21618), Bacillus mycoides (of access aq726 NRRL B - 21664), Bacillus pumilus (of NRRL Access B - 30087), Bacillus pumilus (of access aq717 NRRL B - 21662), Bacillus sp. aq175 (n.Access 55608% TCCA), Bacillus sp.aq177 (ATCC no. Access 35653), Bacillus sp. aq178 (ATCC no. Access 53522), Bacillus subtilis (of access aq743 NRRL B - 21665), Bacillus subtilis (of access aq713 NRRL B - 21661), Bacillus subtilis (of access aq153 ATCC 55614 Bacillus Thurin) Giensis BD # 32 (of access NRRL B - 21530, Bacillus thuringiensis aq52 (n).- Access NRRL B - 21619 muscodor albus), 620 (of access NRRL 30547 muscodor roseus), A3 - 5 (of access 30548 NRRL), Rhodococcus globerulus (of access aq719 NRRL B - 21663), Streptomyces galbus (of access 30232 NRRL), Streptomyces sp. NRRL (of access B - 30145), Bacillus thuring Iensis subspec. Kurstaki BMP 123, Bacillus subtilis aq30002 (n.No. 8 - Access NRRL 50421 30004 (AQ) and Bacillus subtilis.1. Access NRRL B -) and / or a Mutant of these strains have all the identifying characteristics of the respective Strain, and / or a metabolite produced by the strain corresponding to show activity against insects, mites,Plant pathogens and nematodes and / or Fungicide (1) at least one selected from the group consisting of ergosterol biosynthesis inhibitors in a synergistically effective amount. In addition, the present Invention relates to the use of this composition, as well as a procedure for reducing the overall Damage in plants and parts of plants.La presente invención se refiere a una composición que comprende al menos un agente de control biológico seleccionado del grupo que consiste en Bacillus chitinosporus AQ746 (n.° de acceso NRRL B-21618), Bacillus mycoides AQ726 (n.° de acceso NRRL B-21664), Bacillus pumilus (n.° de acceso NRRL B-30087), Bacillus pumilus AQ717 (n