Disclosed herein are heretofore undescribed preparations of highly concentrated,solubilized proteins, such as but not limited to, Bone Morphogenetic Proteins.Such protein preparations can be formulated in an aqueous carrier at proteinconcentrations in excess of 10 mg/ml when using the methods of manufacture taughtherein. Such methods yield stable protein preparations in either solubilizedor lyophilized form. The protein preparations of the present invention are particularlybeneficial when administered either locally or systemically, in part, becauselow administration volumes can be accomplished. This is especially importantfor local treatment of certain anatomic locations such as, for example, the synovialfluid of a joint when treating osteoarthritis with BMP-7 or the intradiscal spacewhen treating degenerative disc disease with BMP-7.
