Targeting c-Rel O-GlcNAcylation and uses thereof

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专利权人:

发明人:

Parameswaran Ramakrishnan,David Baltimore

申请号：

US14166681

公开号：

US09696296B2

申请日:

2014.01.28

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Serine 350 has been identified as the site of O-GlycNAcylation of c-Rel. Methods are provided for identifying compositions capable of blocking c-Rel activation. The methods generally involve identifying compounds that inhibit O-GlcNAcylation of c-Rel at the serine 350 residue, thereby preventing c-Rel activation and production of c-Rel-dependent cytokines.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/