Adrian L. Smith,Elizabeth M. Doherty,Qi Huang,Gang Liu
申请号：
US12663504
公开号：
US08557830B2
申请日:
2008.06.05
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention comprises a new class of compounds capable of modulating the activity of Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula (I) wherein each of A1, A2, A3, A4, A5, A6, A7, A8, A9, bond B, X, rings Z1 and Z2, R1 and R3 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
