A method for managing intervention activities for chronic progressive neurodegenerative conditions that enhance neurophysiological processes of a client includes receiving a client for evaluation and determining a first level of functioning in each of a plurality of cognitive and non-cognitive areas. The method also includes iteratively, determining a program of intervention activities associated with the cognitive and non-cognitive areas based on at least one of the first level of functioning and a generated report of a performance of the intervention activities, the program of intervention activities including one or more intervention activities selected from a plurality of intervention activities, administering the program of intervention activities to the client, and generating a report of a performance of the administered program of intervention activities. The method further includes reporting a progress of the client over time with respect to the performance of the administered program of intervention activities.
