The present invention provides protease-resistant peptides, methods of making such peptides, as well as compositions comprising protease-resistant peptides and method of treatment utilizing such peptides. Incorporation of alpha-methyl-functionalized amino acids directly into the main chain during standard peptide synthesis via the methodologies described herein has been determined to produce protease-resistant peptides.The preferred alpha-methyl-functionalized amino acid is alpha-methyl-Phenylalanine and the preferred peptide is glucagon-like peptide (GLP-1).La presente invención proporciona péptidos resistentes a proteasa, métodos de preparación de tales péptidos, así como composiciones que comprenden péptidos resistentes a proteasa y métodos de tratamiento que utilizan tales péptidos. Se ha determinado que la incorporación de aminoácidos funcionalizados con alfa-metilo directamente en la cadena principal durante la síntesis peptídica convencional mediante las metodologías descritas en la presente produce péptidos resistentes a proteasa.
