The present invention incorporates new materials for bone regeneration, methods for their manufacture, and application in traumatology surgery, maxillofacial surgery, dental surgery, orthognatic surgery, endodontics, ophthalmology, neurosurgery and/or osteoporotic processes, and other indications where bone regeneration is required. In particular, the present invention incorporates synthetic materials with a 20 % to a 95 %, preferably between 40% and 90% in mass of monetite Ca1-XMXHPO4, where 0 = x = 0.05, and where M can be a divalent metallic ion , and which in their final composition incorporate between 5 % and 80 %, preferably between 0 % and 60 %, in mass of bioactive calcium compounds chosen from calcium phosphates and between 5% and 80 % in total mass of bioactive silicon compounds chosen from calcium silicates and/or bioactive silica glasses and gels.
