AMERSHAM HEALTH AS;GE HEALTHCARE AS;NYCOMED IMAGING AS
发明人:
GEORG HANSSON,IB LEUNBACH,JAN HENRIK ARDENKJAER-LARSEN,KLAES GOLMAN,LARS-GÖRAN WISTRAND,OSKAR AXELSSON,STEFAN PETERSSON
申请号：
BR9813244
公开号：
BRPI9813244B1
申请日:
1998.12.23
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
"magnetic resonance imaging process of a sample, preferably of a human or non-human animal body, composition, contrast medium, and administrable composition." This invention provides a magnetic resonance investigation process of a sample, preferably of a human or non-human animal body, said process comprising: (i) producing a hyperpolarized solution of a high dissolution agent in a solvent physiologically tolerable a hyperpolarized solid sample of said high t-agent； (ii) wherein the hyperpolarization of the solid sample of said high t-agent in step (i) is effected by means of a polarizing agent, optionally separating the whole, substantially the whole, or a portion of said polarizing agent. said high t-agent； (iii) administering said hyperpolarized solution to said sample； (iv) exposing said sample to a second radiation of a selected frequency to stimulate nuclear gyrus transitions in the selected nuclei, for example, the high tm-1 rm imaging nuclei； (v) detecting magnetic resonance signals from said sample； and (vi) optionally imaging, dynamic flow data, perfusion data, physiological data (e.g., ph, po ~ 2 ~, pco ~ 2 ~, temperature or ionic concentrations) or metabolic data of said signals. wherein said high t-1 ~ agent in said hyperpolarized solution has a t-1 ~ value (at a field strength in the range 0.01 to 5t and a temperature in the range 20 to 40 ° c) of at minus 5 seconds."processo de investigação por ressonância magnética de uma amostra, preferivelmente de um corpo animal humano ou não humano, composição, meio de contraste, e, composição administrável". esta invenção fornece um processo de investigação por ressonância magnética de uma amostra, preferivelmente de um corpo animal humano ou não humano, dito processo compreendendo: (i) a produção de uma solução hiperpolarizada de uma agente t~ 1~ elevado por dissolver em um solvente fisiologicamente tolerável uma amostra sólida hiperpolarizada de dito agente t~ 1~ elevado； (ii) em que a hiperpolarização da amos
