PROBLEM TO BE SOLVED: To provide a bubble generation device capable of adding oxygen in the vein of a patient without an extracorporeal circulation as a device taking place of an intravenous indwelling type artificial lung.SOLUTION: A bubble generation device 1 can generate microbubbles of oxygen gas G mainly composed of oxygen in the vein of a patient. The bubble generation device 1 includes a bubble generation chip 2 having a surface 2a where a large number of micropores Mp from which the oxygen gas G can flow out are opened, which can guide the supplied oxygen gas G to the large number of micropores Mp, and has a size that allows the insertion into the vein, and an oxygen supply tube 3 composed of a flexible material which can supply the oxygen gas G to the bubble generation chip 2 and has a size that allows the insertion into the vein.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2017,JPO&INPIT【課題】静脈内留置型人工肺に代わる装置として、体外循環を伴わずに患者の静脈内で酸素付加が可能な気泡発生装置を提供する。【解決手段】気泡発生装置1は酸素を主体とする酸素ガスGのマイクロバブルを患者の静脈内で発生させることができる。気泡発生装置1は酸素ガスGが流出可能な多数の微小孔Mpがそれぞれ開口している表面2aを有し、供給された酸素ガスGを多数の微小孔Mpに導くことができ、かつ静脈内に挿入可能な大きさを有する気泡発生チップ2と、柔軟な素材で構成され、気泡発生チップ2に酸素ガスGを供給でき、かつ静脈内に挿入可能な大きさを有する酸素供給チューブ3とを備える。【選択図】図1