UNIVERSITA DEGLI STUDI DI MILANO;UNIVERSITA' DEGLI STUDI DI MILANO
发明人:
ZEMA, LUCIA,PALUGAN, LUCA,SANGALLI, MARIA EDVIGE,GAZZANIGA, ANDREA,DEL CURTO, MARIA DORLY,MARONI, ALESSANDRA
申请号：
ITMI20081313
公开号：
IT1393244B1
申请日:
2008.07.18
申请国别(地区):
IT
年份:
2012
代理人:
摘要：
Said invention refers to a pharmaceutical form for selective colon delivery of drugs or bioactive molecules degraded and/or poorly absorbed in the gastrointestinal tract. The system comprises a core consisting of the active ingredient, and a protease inhibitor layer and/or an absorption enhancer layer, said core being separated from these layers by means of a polymer that swells and/or dissolves and/or is degraded when in contact with the biological fluids present in the gastro-intestinal tract； depending on the thickness of the polymeric layer, the release of the drug can be modulated with respect to the inhibitor and/or promoter.
