PETER BRÜNKER,CLAUDIA FERRARA KOLLER,PABLO UMANA,TOBIAS SUTER,ÚRSULA PÜNTENER,EKKEHARD MÖSSNER
申请号：
PT04185277
公开号：
PT2380910E
申请日:
2004.11.05
申请国别(地区):
PT
年份:
2015
代理人:
摘要：
The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human CD20. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
