Methods and systems for recovery-adaptive biobehavioral-regulation treatments for relapse. In various embodiments, a user wears a sensor that collects biobehavioral data regarding the user and is operatively connected to an electronic computing device associated with the user. Generally, the disclosed system monitors the collected biobehavioral data to mitigate relapse of a previous disease and/or disorder (e.g., addiction, depression, post-traumatic stress disorder, etc.) by presenting personalized recovery cues (e.g., images, videos, etc.) to the user when the user is experiencing stimuli that increase the risk of relapse. In addition, the user has the ability to modulate the implicated brain structure image interactively on the smartphone interface (e.g., changing the size, texture, color, image), in order to change its functionality in real-time and improve in-the-moment emotional regulation. By presenting the personalized recovery cues, in various embodiments, the risk of relapse in the user can be reduced.