Disclosed is a cyclic dipeptide-containing composition comprising specific amounts of: tyrosine-containing cyclic dipeptides selected from the group consisting of cyclotryptophanyltyrosine, cycloseryltyrosine, cycloprolyltyrosine, cyclotyrosylglycine, cyclotyrosyltyrosine, cyclophenylalanyltyrosine, cycloleucyltyrosine, cyclolysyltyrosine, cyclohistidyltyrosine, cycloalanyltyrosine, cycloglutamyltyrosine, cyclovalyltyrosine, cycloisoleucyltyrosine, cyclothreonyltyrosine, cycloaspartyltyrosine, cycloasparaginyltyrosine, cycloglutaminyltyrosine, cycloarginyltyrosine, and cyclomethionyltyrosine or salts thereof. This cyclic dipeptide-containing composition has an excellent uric acid level lowering effect, and is useful for, for example, the prophylaxis or treatment of hyperuricemia, gout, etc.本發明為將含有選自由環色胺醯基酪胺酸、環甘油基酪胺酸、環脯胺醯基酪胺酸、環酪胺醯基甘胺酸、環酪胺醯基酪胺酸、環苯丙胺基酪胺酸、環白胺醯基酪胺酸、環離胺醯基酪胺酸、環組胺醯基酪胺酸、環丙胺醯基酪胺酸、環麩胺醯基酪胺酸、環纈胺醯基酪胺酸、環異白胺醯基酪胺酸、環蘇胺醯基酪胺酸、環天冬胺醯基酪胺酸、環天冬醯胺醯基酪胺酸、環麩醯胺醯基酪胺酸、環精胺醯基酪胺酸以及環甲硫胺醯基酪胺酸所成之群的酪胺酸之環狀二肽或其鹽,分別以特定量來含有之含有環狀二肽之組成物。本發明之含有環狀二肽之組成物具有優異之尿酸值降低作用,且有用於例如高尿酸血症或痛風等之預防或治療。
