Stavros Topouzis;Debra G. Gilbertson;Charles E. Hart
发明人:
Charles E. Hart,Stavros Topouzis,Debra G. Gilbertson
申请号：
US12780809
公开号：
US08298534B2
申请日:
2010.05.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Materials and Methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
