Soluble RNA cap binding pocket fragment and use thereof

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专利权人:

ヨーロピアン モレキュラー バイオロジー ラボラトリー

发明人:

キューザック，ステファン,グイリガイ，ディルフィーヌ,ハート，ダレン,タレンデュー，フランク,キューザック,ステファン,グイリガイ,ディルフィーヌ,ハート,ダレン,タレンデュー,フランク

申请号：

JP2016094331

公开号：

JP6309563B2

申请日:

2016.05.10

申请国别(地区):

JP

年份:

2018

代理人:

摘要：

The present invention relates to soluble fragments of the Influenza virus RNA dependent RNA polymerase subunit PB2 and variants thereof, and crystallized complexes thereof comprising an RNA cap analog. This invention also relates to computational methods using the structural coordinates of said complex to screen for and design compounds that interact with the RNA cap binding pocket. In addition, this invention relates to methods identifying compounds that bind to PB2 polypeptide fragments comprising the RNA cap binding pocket, preferably inhibit the interaction with RNA caps or analogs thereof, by using said PB2 polypeptide fragments, preferably in a high-throughput setting. This invention also relates to compounds and pharmaceutical compositions comprising the identified compounds for the treatment of disease conditions due to viral infections caused by negative-sense single stranded RNA viruses.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/