ШМИТЦ Гарольд Х. (US),КВИК-УРИБЕ Кэтрин Л. (US),ШРЕТЕР Хаген (US)
申请号：
RU2012137517/15
公开号：
RU2012137517A
申请日:
2012.09.03
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method of treating a condition associated with elevated levels and / or arginase activity in a subject in need thereof, comprising administering to the subject a composition comprising an effective amount of at least one compound selected from the group consisting of a polymer compound having the formula A , its pharmaceutically acceptable salt and its derivative: where n is an integer from 2 to 18； each of R and X has either α or β stereochemistry； R is OH, O-sugar or O-gallate； substituents C-4, C -6 and C-8 are X, Z and Y respectively obviously, and the binding of monomer units occurs at position C-4, C-6 or C-8； when any of C-4, C-6 or C-8 is not bound to another monomer unit, X, Y and Z are hydrogen or sugar； Isahar is optionally substituted with a phenolic group. 2. A method of treating a condition associated with elevated levels and / or arginase activity in a subject in need thereof, comprising administering to the subject a composition comprising an effective amount of at least one compound selected from the group consisting of epicatechin, catechin, its pharmaceutically acceptable salt and a derivative thereof, the derivative being not a gallic acid derivative. 3. The method according to claim 1, in which the subject is a person. The method of claim 2, wherein the subject is a human. The method of claim 4, wherein the compound is epicatechin and / or a pharmaceutically acceptable salt thereof. The method of claim 2, wherein the derivative is a methylated derivative. The method according to claim 6, in which the methylated derivative is selected from the group consisting of 3'-O-methyl - (+) - catechin, 3'-O-methyl - (-) - epicatechin, 4'-O-methyl- ( +) - category1. Способ лечения состояния, ассоциированного с повышенными уровнями и/или активностью аргиназы у субъекта, нуждающегося в этом, включающий введение субъекту композиции, содержащей эффективное количество, по меньшей мере, одного соединения, выбранного из группы, состоящей из полимерного соедин
