A system for inducing a negative pressure in a portion of an urinary tract of a patient including: a ureteral catheter (112,114) comprising a distal portion (118) for insertion within the patient's kidney and a proximal portion; a bladder catheter (116) comprising a distal portion to be positioned in the patient's bladder and a proximal portion for application of a negative pressure, the proximal portion extending outside the patient's body; and a pump (710) external to the patient's body for application of negative pressure at the proximal end of the bladder catheter, wherein the pump induces negative pressure through both the bladder catheter and the ureteral catheter, which in turn causes fluid from the kidney to be drawn into the ureteral catheter, through both the ureteral catheter and the bladder catheter, and then outside the patient's body.