48 METHOD FOR ACTIVATION OF HELPER T CELL AND COMPOSITION FOR USE IN THE METHOD ABSTRACT DISCLOSED ARE: A METHOD FOR ACTIVATING A HELPER T CELL, WHICH COMPRISES THE STEP OF ADDING A WTI PEPTIDE TO AN ANTIGEN-PRESENTING CELL TO ACTIVATE THE HELPER T CELL, WHEREIN THE WTI PEPTIDE IS CAPABLE OF BINDING TO ANY ONE SELECTED FROM AN HLA-DRBI*1501 MOLECULE, AN HLA-DPBI*0901 MOLECULE AND AN HLA-DPBLIO501 MOLECULE; A COMPOSITION FOR USE IN THE METHOD; A THERAPEUTIC AND/OR PROPHYLACTIC METHOD FOR CANCER BY ACTIVATING A HELPER T CELL; A PHARMACEUTICAL 10 COMPOSITION FOR USE IN THE THERAPEUTIC AND/OR PROPHYLACTIC METHOD; AND OTHERS.