YAN, SHUNQI,SAUNDERS, JEFFREY O.,SALITURO, FRANCESCO G.
申请号：
ARP180102600
公开号：
AR112803A2
申请日:
2018.09.13
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
1. The compounds in this table are composed of piruvato cinasa M2 (pkm2). It also introduces the use of pkm2 compounds in cancer treatment. 1. Claim 1: a formula compound (1),Or a salt acceptable for the same agent, marked with W, x, y and Z independently selected from CH or N； D and D1 independently selected from NR 74955；A optional bicyclic alternative, l is a link, - C (o)-（Cr 7580；R7580）-8344；-，-OC (o)..-（Cr 7580）；R7580）-8344；-OC（o）-，-（Cr7580）；R7580）-8344；-C（o）-，-No. 7495； - C (s),o-NR 7495；c（o）-；R1 was selected from asphalt, cyclopropyl compound, arilo, isopropyl and isopropyl, and each asphalt was replaced by r74966 for 0-5 times；Each rw-3 is selected from the adjacent halides, halides, asphalt, hydrocarbon, hydroxyl and / or 2r7491 or 2m3 together with the attached carbon atoms to form an alternative bicycle substitute； each r74919 is selected from the asphalt, acid, hydroxide and halide independently； each r7495se； 1. Choose independently from hydrogen and tar, choose independently from hydrogen, halogen, tar, oxygen and halogen oxygen for each r758080, or form an alternative cyclopentane chemical substitute together with the carbon atoms attached to them；Each r74966 is independently selected from halogenated tar, halogenated alcoxi, asphalt, tar, nitric acid, cyanogen, hydroxy-C (o) r74919；-OC（O）R74919，-C（O）Or7491，-7491,-No. 7491； r7491 and r74919；O two r74966 are combined with carbon atoms to form an alternative n o n bicycle alternative； n is 0, 1 or 2； m is 1, 2 or 3； h is 0, 1, 2； G is 0, 1 or 2.La presente se refiere a compuestos y composiciones que comprenden compuestos que modulan a piruvato cinasa M2 (PKM2). También se describen métodos para usar los compuestos que modulan PKM2 en el tratamiento de cáncer. Reivindicación 1: Un compuesto de la fórmula (1), o una sal del mismo farmacéuticamente aceptable, caracterizado porque W, X, Y y Z son cada uno independientemente seleccionados a partir de CH o N； D y D¹ son independientemente seleccionados a pa
