fused pyrrolidine cyclopropane derivatives, drug, pharmaceutical composition, and kit

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专利权人:

MERCK PATENT GMBH

发明人:

Denis Carniato,Didier Roche,Eric Valeur,Fabien Schmidlin,Franck Lepifre,Serge Christmann-Franck

申请号：

BRPI0918288

公开号：

BRPI0918288B1

申请日:

2009.08.05

申请国别(地区):

BR

年份:

2018

代理人:

摘要：

The present invention relates to fused pyrrolidino-cyclopropane derivatives according to formulae (I) to (IV) as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-HSD-1) and the use of such compounds for the treatment and/or prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.

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