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Compounds that have agonism towards the thrombopoietin receptor
专利权人:
SHIONOGI & CO.; LTD.
发明人:
TAKAYAMA, Masami,YOSHIDA, Yutaka
申请号:
ES04771440
公开号:
ES2599529T3
申请日:
2004.08.10
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound represented by the general formula (II): ** Formula ** in which RA is a hydrogen atom, C1-C12 alkyloxy, (C1-C8) alkyloxy-(C1-C8) alkyloxy or (C1- alkyloxy C8) - (C1-C8) alkyloxy) - (C1-C8) alkyloxy; RB is C1-C14 alkyl optionally substituted with one or two substituents selected from group of substituents B, C2-C14 alkynyl optionally substituted with one or two substituents selected from group of substituents B, C3-C8 cycloalkyl, optionally substituted with one or two substituents selected from the group of substituents B, phenyl or naphthyl; RC is a hydrogen atom, a halogen atom, C1-C6 alkyl, or C1-C12 alkyloxy; RD is a hydrogen atom, a halogen atom, C1-C3 alkyl, or C1-C3 alkyloxy; both of R6 and R7 are a fluorine atom or a chlorine atom; R8 is C1-C3 alkyl or C1-C3 alkyloxy; group of substituents B consists of a halogen atom, C3-C8 cycloalkyl, C3-C8 cycloalkenyl, phenyl, naphthyl, pyridyl, oxolanyl, cyano, C1-C8 alkyloxy, C2-C8 alkenyloxy, cycloalkyl (C3 -C8) - (C1-C8) alkyloxy, phenyl-(C1-C8) alkyloxy, naphthyl-C1-C8 alkyloxy, (C1-C8) alkyloxy (C1-C8) alkyloxy, (C1-C8 alkyloxy) - (C1-C8) alkyloxy) - (C1-C8) alkyloxy, di (C1-C8 alkyloxy) (C1-C8) alkyloxy, oxolanyl-(C1-C8) alkyloxy, halo-C1-C8 alkyloxy, cycloalkyloxy C3-C8, amino optionally substituted with C1-C8 alkyl, C1-C8 alkylthio, and (C1-C8) alkylthio-(C1-C8) alkyloxy; a pharmaceutically acceptable salt or a solvate thereof.Un compuesto representado por la fórmula general (II):**Fórmula** en la que RA es un átomo de hidrógeno, alquiloxi C1-C12, alquiloxi(C1-C8)-alquiloxi(C1-C8) o (alquiloxi(C1-C8)- alquiloxi(C1-C8))-alquiloxi(C1-C8); RB es alquilo C1-C14 opcionalmente sustituido con uno o dos sustituyentes seleccionados del grupo de sustituyentes B, alquinilo C2-C14 opcionalmente sustituido con uno o dos sustituyentes seleccionados del grupo de sustituyentes B, cicloalquilo C3-C8, alquiloxi C1-C14 opcionalmente sustituido con uno o dos sustituyentes seleccionados del grupo de sustituyentes B, fenilo
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