The invention provides an in vitro method for (a) inducing differentiation of CNS progenitor / precursor cells into CNS cells, (b) improving proliferation of CNS cells or CNS progenitor / precursor cells, or (c) improving survival of CNS cells or CNS progenitor / precursor cells, comprising contacting said cells with (i) a BRD7 antagonist, or (ii) an Ikaros antagonist. The invention further provides a composition comprising (i) a BRD7 antagonist, and/or (ii) an Ikaros antagonist, for use in a method of: (a) treating or preventing a central nervous system (CNS) cell disease, disorder or condition, or a symptom thereof, in a patient； (b) treating an injured CNS tissue in a patient； (c) engraftment of CNS cells, or CNS progenitor / precursor cells thereof, in a CNS tissue of a subject； (d) improving proliferation of CNS cells, or CNS progenitor / precursor cells thereof, in a CNS tissue of a subject； or (e) increasing CNS cell mass in a CNS tissue of a subject.
