The Board of Trustees of the Leland Stanford Junior University
发明人:
Ravindra Majeti,Emily Piccione Griffin
申请号：
US15502475
公开号：
US10087257B2
申请日:
2015.08.07
申请国别(地区):
US
年份:
2018
代理人:
摘要：
SIRPabodies comprise an immunoglobulin variable region, which may specifically bind a tumor antigen, viral antigen, etc., fused to a sequence comprising a binding domain of SIRPα. The binding domain of SIRPα comprises at least the N-terminal Ig-like domain of SIRPα, and may further comprise additional SIRPα sequences. The SIRPabodies find use in therapeutic methods that benefit from the combined activity of blocking CD47 activity, and antibody targeting, e.g. in the treatment of cancer, etc. In some specific embodiments, the SIRPabody comprises anti-CD20 activity and a SIRP binding domain； anti-CD99 and a SIRP binding domain； or anti-TIM3 activity and a SIRP α binding domain.
