John Ogez,Jun Liu,Wenchang Ji,Patrick Daniel Begley,Isaias Prado,Mark Manning
申请号：
US15793976
公开号：
US20180043020A1
申请日:
2017.10.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention is directed to methods for reducing immunogenicity of a drug product, utilizing filling a container wherein the filled container has no headspace. The present invention is further directed to methods for stabilizing an aqueous drug substance solution by filling a container with the aqueous drug substance solution wherein the filled container has no headspace. The present invention is further directed to formulations of drug substances with reduced immunogenicity.
