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SYNTHESIS AND USE OF KINASE INHIBITORS
专利权人:
PONIARD PHARMACEUTICALS INC
发明人:
LEI YIXIONG,BEHRENS CARL HENRY,LI HUI YIN
申请号:
ZA201300012
公开号:
ZA201300012B
申请日:
2013.01.02
申请国别(地区):
ZA
年份:
2013
代理人:
摘要:
An improved synthesis of a class of inhibitor of Focal Adhesion Kinase (FAK) is provided, wherein use of an expensive palladium-based catalyst is reduced and reaction yields and product purities are improved. Two key reactions of coupling of aryl halides with anilines are optimized with the surprising discovery that the palladium-based catalyst can be dispensed with entirely in one of the reactions. The invention also provides the use of the FAK-inhibitory compounds in the treatment of inflammatory and immune disorders and of arthritis.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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