The invention relates to an activating mechanism in a medicament delivery device (1), wherein the activating mechanism comprises:- a hollow injection needle (5),- a cartridge (2) containing a dosage of a medicament,- a cartridge carrier (6) comprising at least one resilient arm (6.1) for holding the cartridge (2),- a removable needle cap (7) for covering the injection needle (5), and- a drive element (8) adapted to couple with the cartridge (2),- wherein the cartridge (2) is retained in a position spaced apart from the injection needle (5) in a proximal direction (P) by the at least one resilient arm (6.1) when the medicament delivery device (1) is in an initial position (P1), and- wherein by removing the needle cap (7), the cartridge (2) is releasable to be pushed into a distal direction (D) by the drive element (8) with respect to the cartridge carrier (6).Furthermore, the invention relates to a medicament delivery device (1) comprising such an activating mechanism.