The application relates to the compounds and pharmaceutically acceptable salts thereof, as well as their use in medicine, especially as the antitube of Trk (tropiosin). 1. Claim 1: a formula compound (1),Where Q1 is n or CR1；what is it?R1,R2,R83088 and r830909, respectively h, halogen, CN, oh, nh832222；C₁₋₃ alkyl optionally substituted with one or more F, C₃₋₇ cycloalkyloxy optionally substituted with one or more F, or C₁₋₃ alkoxy optionally substituted with one or more F； R³ is H, halogen, CN, C₁₋₄ alkyl optionally substituted with one or more F, C₁₋₄ alkoxy optionally substituted with one or more F, C₃₋₇ cycloalkyloxy optionally substituted with one or more F, or C₁₋₄ alkylthio optionally substituted with one or more F, provided that at least 2 of R¹,R2,R3,e. R8308y and r8309sean h； O, ch8322； O uoch 83222；R8310a and r8311a may combine anywhere in the ring and are independent h, F, CN, oh, n8322；C₁₋₃ alkyl optionally substituted with one or more F, or C₁₋₃ alkoxy optionally substituted with one or more F, or R⁶ and R⁷ can be taken together with the atoms to which they are attached to form a cycloalkane ring of 3 to 7 members； X is CR¹⁰¹ or N； R¹⁰¹ is H or C₁₋₃ alkyl； Z is CH₂,CH (CH)NH u O A es C (O) NR RR¹⁰³ and R¹⁰⁴ are each independently selected from H, (C₁₋₆ alkyl optionally substituted with OH, C₁₋₆ alkoxy, CN or with one or more F) and (C₃₋₇ cycloalkyl optionally substituted with OH, C₁₋₆ alkoxy or with one or more F)；Or a salt that can be accepted from a drug point of viewLa presente solicitud se refiere a compuestos y sus sales aceptables desde el punto de vista farmacéutico, y su uso en medicina, en particular, como antagonistas de Trk (Tropomiosina). Reivindicación 1: Un compuesto de la fórmula (1), en donde Q¹ es N o CR¹； Q² es N o CR²； R¹, R², R⁴ y R⁵ son, cada uno independientemente, H, halógeno, CN, OH, NH₂, C₁₋₃ alquilo opcionalmente sustituido con uno o más F, C₃₋₇ cicloalquiloxi opcionalmente sustituido con uno o más F, o C₁₋₃ alcoxi opcionalment
