Fillatreau, Simon,Uckert, Wolfgang,Kieback, Elisa,Anderton, Stephen,Lampropoulou, Vicky,Stervbo, Ulrik,Bunse, Mario
申请号：
EP20120175113
公开号：
EP2660250(B1)
申请日:
2012.07.05
申请国别(地区):
欧洲专利局
年份:
2018
代理人:
摘要：
The invention relates to the field of transgenic mammals, methods for investigating T-cell therapeutic function and screening active substances useful in the treatment of immune diseases, preferably autoimmune diseases. The invention relates to a transgenic non-human mammal comprising a transgenic expression construct coding for a MOG-binding T-cell receptor (TCR) ² chain, a T-cell receptor (TCR) protein or nucleic acid that encodes said TCR that is isolated from said transgenic non-human mammal and a method for screening one or more factors for involvement in T-cell therapeutic function in an immune disease.
