Molecular signature of cutaneous pigment spots associated with extracellular matrix

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专利权人:

ロレアル

发明人:

ベルナード， フランソワーズ,デュヴァル， クリスティーヌ,ドゥ ラシェリエ， オリヴィエ,ヌーヴォー， ステファニー,マラ， グザヴィエ,ベルナード, フランソワーズ,デュヴァル, クリスティーヌ,ドゥ ラシェリエ, オリヴィエ,ヌーヴォー, ステファニー,マラ, グザヴィエ

申请号：

JP2014505704

公开号：

JP6181042B2

申请日:

2012.04.20

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

The present invention concerns a molecular signature of cutaneous pigmentary spots, comprising the genes TGFBR2, TGFBI, BMP2, SMAD3, THBS2, TGFBR3, SEMA5A, SMAD7, SOSTDC1, FRAS1, LEPREL1, MATN2, DST, PLOD2, ITGA2, COL6A3, CRTAP, LAMC1, LAMB3, LAMA3, ITGAV, ITGB1 and ACTN1, and various applications of this signature. In particular, the invention concerns a method for characterizing a known or suspected pigmentary spot in a human being, comprising comparing the levels of expression in skin samples obtained from said spot and from adjacent undamaged skin, of at least one dermal gene linked to the extracellular matrix selected from the list constituted by the genes TGFBR2, TGFBI, BMP2, SMAD3, THBS2, TGFBR3, SEMA5A, SMAD7, SOSTDC1, FRAS1, LEPREL1, MATN2, DST, PLOD2, ITGA2, COL6A3, CRTAP, LAMC1, LAMB3, LAMA3, ITGAV, ITGB1 and ACTN1. The invention also concerns methods for evaluating the efficacy of a pigmentary spot treatment, cosmetic and therapeutic methods for the treatment of pigmentary spots, and various modulators for said genes, and their use.

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