The present disclosure generally includes a crosslinked cation binding polymer comprising a monomer containing a carboxylic acid group and a pKa reducing group (including an electron withdrawing substituent such as a halide atom (eg, fluorine)) and a base. For compositions comprising, the polymer optionally contains less than about 20,000 ppm non-hydrogen cations and the base is from about 0.2 equivalents to about 0.95 equivalents of base per equivalent of carboxylic acid group in the polymer. Present in an amount sufficient to provide. The present disclosure also relates to methods for preparing the composition and methods for using the composition to treat various diseases or disorders. [Selection figure] None本開示は、概して、カルボン酸基とｐＫａ低下基（ハロゲン化物原子（例えば、フッ素）等の電子求引性置換基を含む）とを含有するモノマーを含む架橋型カチオン結合性ポリマーと塩基とを含む組成物に関し、このポリマーは、任意で、約２０，０００ｐｐｍ未満の非水素カチオンを含有し、塩基は、ポリマー中のカルボン酸基１当量当たり約０．２当量～約０．９５当量の塩基を提供するのに十分な量で存在する。本開示はまた、当該組成物の調製方法、および種々の疾患もしくは障害を治療するために当該組成物を使用する方法にも関する。【選択図】なし
